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UHPLC quantitation method for new thiazolidinedione LPSF/GQ-02 and in vitro/in vivo kinetic studies
(2016-09-01)
Background: LPSF/GQ-02 is a promising benzylidene thiazolidinedione that has demonstrated antidiabetic,antidyslipidemic,anti-atherosclerotic properties and can also treat non-alcoholic fatty liver disease. Despite all ...
Therapeutic Actions of the Thiazolidinediones in Alzheimer's Disease
(Hindawi Publishing Corporation, 2015)
New pioglitazone metabolites and absence of opened-ring metabolites in new n-substituted thiazolidinedione
(2018-06-01)
Thiazolidinediones (TZDs) are drugs used to treat type 2 diabetes mellitus; however, several safety concerns remain regarding the available drugs in this class. Therefore, the search for new TZD candidates is ongoing; ...
Diabetes melito, tiazolidinedionas e fraturas: uma história inacabada
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010-06-01)
The association of diabetes mellitus with increased fracture risk is well established, and is observed in both diabetes type 1 and type 2, due to multiple causes. Evidence from rodents suggests that thiazolidinediones ...
Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells
(Elsevier Inc, 2014-06)
The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors involved in lipid metabolism and glucose utilization, in cell growth, differentiation and apoptosis, and in the regulation ...
Obesity, diabetes mellitus and last but not least, osteoporosis
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010)
Knowledge about the influence of bone on intermediary metabolism corresponds to a developing area that has gained prominence. The old concept of bone and adipose tissues as inert metabolic tissues, with minor contributions ...