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Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function
(Wiley VCH Verlag, 2008-11)
Galectin-1 has been implicated in regulating T-cell survival, function, and Th1/Th2 balance in several mouse models, though the molecular and cellular basis of its immunomodulatory activity has not been completely ...
Seeing through the parasites' eyes
(Nature Pub. Group, 2020)
The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response
(Associação Brasileira de Divulgação Científica, 2001-04-01)
In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice. T cell ...
Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization
(Wiley VCH Verlag, 2012-06)
Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we ...
Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection
(Elsevier B.V., 2015-08-01)
The discovery of Th17 cells, along with many other Th cell subsets in the recent years, has expanded the Th1/Th2 paradigm that had persisted since its proposition by Mosmann in 1986. Defined by the characteristic expression ...
Influência da prostaglandina E2 na plasticidade de linfócitos Th17/Th1 no contexto da encefalomielite autoimune experimental
(Universidade Estadual Paulista (Unesp), 2019-05-16)
A prostaglandina E2 (PGE2) é um mediador lipídico que participa tanto na diferenciação como na expansão de linfócitos T helper (Th) Th1 e Th17. Esse prostanoide vem sendo descrito como um importante mediador envolvido no ...