Buscar
Mostrando ítems 1-10 de 1785
Signaling properties of a covalent modification cycle are altered by a downstream target
(National Academy of Sciences, 2010-06)
We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a ...
Actin Filaments—A Target for Redox Regulation
(Wiley, 2016)
Actin and its ability to polymerize into dynamic filaments is
critical for the form and function of cells throughout the
body. While multiple proteins have been characterized as
affecting actin dynamics through noncovalent ...
Breast Cancer Targeting of a Drug Delivery System through Postsynthetic Modification of Curcumin@N3-bio-MOF-100 via Click Chemistry
(2021-08-16)
Metal-organic frameworks (MOFs) offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, and their high level ...
Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: Understanding the action of the inhibitor GC7 on a murine macrophage cell line
(2014-01-30)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...
Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line
(Bentham Science Publ Ltd, 2014-01-01)
Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative ...