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Tumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(2009)
Background and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the ...
Dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic chagas cardiomyopathy
(Karger, 2018-12)
Individuals who are infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and ...
Periapical lesions decrease insulin signal and cause insulin resistance
(2013-05-01)
Introduction: Inflammatory cytokines are associated with decreased insulin signal transduction. Moreover, local oral inflammation, such as that accompanying periodontal disease, is associated with insulin resistance and ...
Modulation of mammalian circadian rhythms by tumor necrosis factor-α
(Taylor, 2014-06)
Systemic low doses of the endotoxin lipopolysaccharide (LPS, 100 µg/kg) administered during the early night induce phase-delays of locomotor activity rhythms in mice. Our aim was to evaluate the role of tumor necrosis ...
Tumor necrosis Factor Receptor-1 (p55) deficiency attenuates tumor growth and intratumoral angiogenesis and stimulates CD8+ T cell function in melanoma
(MDPI, 2020-11)
The role of tumor necrosis factor-α (TNF-α) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-α plays a dual role, either acting as a cytotoxic cytokine or favoring a ...
TNF-alpha affects signature cytokines of th1 and th17 t cell subsets through differential actions on TNFR1 and TNFR2
(MDPI, 2022)
Tumor necrosis factor (TNF)- is a pleiotropic cytokine implicated in the etiology of
several autoimmune diseases, including rheumatoid arthritis (RA). TNF- regulates diverse effector
functions through the activation ...
Efecto de metformina sobre la expresión del factor de necrosis tumoral-a, los receptores Toll-like 2/4 y la PCR ultra sensible en sujetos obesos con diabetes tipo 2
(2012)
Background: The pharmacological action of metformin goes beyond mere
glycemic control, decreasing markers of inflammation and contributing to the
reduction of oxidative stress. Aim: To evaluate biochemical, anthropometric ...
Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer
(2019-04-01)
BACKGROUND Gastric carcinogenesis can be induced by chronic inflammation triggered by Helicobacter pylori (H. pylori) infection. Tumor necrosis factor (TNF)-α and its receptors (TNFR1 and TNFR2) regulate important cellular ...