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Inhibition of human topoisomerase I and activation of caspase-3 by aza-angucyclinones and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones

Monsalve, Francisco A.; Valderrama, Jaime A.; Vasquez, David; Ibacache, Andrea; Rodriguez, Jaime A.; Gonzalez, Daniel R.; Leiva, Elba; Gonzalez, Enrique (SPANDIDOS PUBL LTD, 2012)

Cancer is the second cause of death in the world after cardiovascular diseases. Cancer cells acquire capacities not present in normal cells, such as self-sufficiency, resistance to antiproliferative stimuli, evasion of ...