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TRYPANOSOMA-CRUZI TRANS-SIALIDASE GENE LACKING C-TERMINAL REPEATS and EXPRESSED in EPIMASTIGOTE FORMS
(Elsevier B.V., 1995-03-01)
Infective trypomastigote forms of Trypanosoma cruzi express an oligomeric trans-sialidase that contains a long stretch of 12-amino-acid repeats at the C terminus, while the insect epimastigote forms have a monomeric ...
Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite
(Elsevier, 2011-09)
A dense glycocalix covers the surface of Trypanosoma cruzi, the agent of Chagas disease. Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize ...
Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
(Frontiers Media S.A., 2016-03)
Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, ...
Synthesis of oseltamivir conjugates with lactose analogs for inhibition studies on Trypanosoma cruzi trans-sialidase
(Arkat USA, 2011-03)
Trypanosoma cruzi, the agent of Chagas disease, expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite. Crystallographic studies ...
Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase
(Springer, 2010-07)
Trypanosoma cruzi, the agent of Chagas disease, expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite. The enzyme is shed to the ...
Substrate specificity of the Trypanosoma cruzi trans-sialidase
(Oxford University Press, 2019)
Free energy computations identify the mutations required to confer trans-sialidase activity into Trypanosoma rangeli sialidase
(Wiley, 2013-10)
Trypanosoma rangeli's sialidase (TrSA) and Trypanosoma cruzi's trans-sialidase (TcTS) are members of the glycoside hydrolase family 33 (GH-33). They share 70% of sequence identity and their crystallographic Cα RMSD is 0.59 ...
Trans-sialidase neutralizing antibodies detection in Trypanosoma cruzi infected domestic reservoirs.
(American Society for Microbiology, 2011-06)
The detection of Trypanosoma cruzi infection in domestic dogs and cats is relevant to evaluating human transmission risks and the effectiveness of insecticide spraying campaigns. However, the serological assays routinely ...