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Transmembrane domain dimerization induces cholesterol rafts in curved lipid bilayers
(Royal Society of Chemistry, 2019-01)
Are the dimerization of transmembrane (TM) domains and the reorganization of the lipid bilayer two independent events? Does one event induce or interfere with the other? In this work, we have performed well-tempered ...
Role of transmembrane proteins for phase separation and domain registration in asymmetric lipid bilayers
(2019-08-01)
It is well known that the formation and spatial correlation of lipid domains in the two apposed leaflets of a bilayer are influenced by weak lipid–lipid interactions across the bilayer’s midplane. Transmembrane proteins ...
The shape of the transmembrane domain is a novel endocytosis signal for single-spanning membrane proteins
(Company of Biologists, 2017-11-15)
Endocytosis is crucial for all cells as it allows them to incorporate material from the extracellular space and control the availability of transmembrane proteins at the plasma membrane. In yeast, endocytosis followed by ...
Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...
Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex
(Company Of Biologists, 2013-12)
It is still unclear why some proteins that travel along the secretory pathway are retained in the Golgi complex whereas others make their way to the plasma membrane. Recent bioinformatic analyses on a large number of ...
Critical role of the first transmembrane domain of cx26 in regulating oligomerization and function
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)