Buscar
Mostrando ítems 1-10 de 271
Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma
(FUNPEC-EDITORA, 2009)
Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, ...
The expression of Delta NTP73, TATP73 and TP53 genes in acute myeloid leukaemia is associated with recurrent cytogenetic abnormalities and in vitro susceptibility to cytarabine cytotoxicity
(WILEY-BLACKWELL, 2008)
TP73 encodes for two proteins: full-length TAp73 and Delta Np73, which have little transcriptional activity and exert dominant-negative function towards TP53 and TAp73. We compared TATP73 and Delta NTP73 expression in acute ...
Expressão dos genes MDR-1, TP53, BCL-2 e BAX em tumor venéreo transmissível canino e sua relação com a agressividade e resposta à terapia
(Universidade Estadual Paulista (Unesp), 2014-11-21)
Transmissible venereal tumor - TVT has been subject of numerous investigations, despite this, there are gaps that need studies. There TVTs with varying degrees of aggressiveness, so some do not respond to conventional ...
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft of Lip and Palate: Exclusion of SHH, TGIF, SIX3, GLI2, TP73L, and DHCR7 as Candidate Genes
(WILEY-LISS, 2009)
We describe a Brazilian boy with semilobar holoprosencephaly, ectrodactyly, bilateral cleft of lip and palate, and severe mental retardation. The karyotype was normal and the screening for mutations in the genes SHH, TGIF, ...
TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer
(B M J Publishing Group, 2017-07)
Aim: Accumulated evidence suggests that aberrant methylation of the TP73 gene and increased levels of ΔNp73 in primary tumours correlate with poor prognosis. However, little is known regarding the transcriptional and ...
DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance
(Springer, 2010-02)
Aberrant DNA methylation is considered an important epigenetic mechanism for gene inactivation. Monoclonal gammopathy of undetermined significance (MGUS) is believed to be a precursor of multiple myeloma (MM). We have ...
Estudo de polimorfismo do gene da triptofano hidroxilase 2 (TPH2) em idosos com depressão de inicio tardio.
(Universidade Federal de Minas GeraisUFMG, 2007-07-13)