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Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis

Oliveira-Costa, Joao Paulo; Oliveira, Lucinei Roberto; da Silveira, Giorgia Gobbi; Soave, Danilo Figueiredo; Soares, Fernando Augusto; Ribeiro-Silva, Alfredo (WILEY-BLACKWELLHOBOKEN, 2013-08-02)

BACKGROUND: The relationship between predictive proteins and tumors presenting cancer stem cells (CSCs) profiles in oral tumors is still poorly understood. This study aims to identify the relationship between topoisomerases ...

Further Constituents Of Galianthe Thalictroides (rubiaceae) And Inhibition Of Dna Topoisomerases I And Iiα By Its Cytotoxic β-carboline Alkaloids.

de Oliveira Figueiredo, Patrícia; Perdomo, Renata Trentin; Garcez, Fernanda Rodrigues; de Fatima Cepa Matos, Maria; de Carvalho, João Ernesto; Garcez, Walmir Silva (2014)

Estudo da Interação com o DNA e Inibição da Atividade Topoisomerase I de Derivados Tiazacridínicos e Imidazacridínicos

Lafayette, Elizabeth Almeida (Universidade Federal de Pernambuco, 2015)

Caracterização das DNA topoisomerases II de Trypanosoma rangeli

Stoco, Patrícia Hermes (2012)

Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase II alpha and active caspase-3

Coelho, Raquel Autran [UNIFESP]; Focchi, Gustavo Rubino de Azevedo [UNIFESP]; Nogueira-de-Souza, Naiara Corrêa [UNIFESP]; Sartori, Marair Gracio Ferreira [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP] (I R O G Canada, Inc, 2008-01-01)

Purpose: To study the relationship between topoisomerase II alpha, active caspase-3 expressions and HPV DNA in uterine cervices with low-grade squamous intraepithelial lesions (LSIL). Methods: Forty women with LSIL and 32 ...

Inhibition of DNA topoisomerase I activity and induction of apoptosis by thiazacridine derivatives

Barros, Francisco Washington Araujo; Bezerra, Daniel Pereira; Ferreira, Paulo Michel Pereira; Cavalcanti, Bruno Coelho; Silva, Teresinha Gonçalves da; Pitta, Marina Galdino da Rocha; Lima, Maria do Carmo Alves de; Galdino, Suely L; Pitta, Ivan da Rocha; Lotufo, Letícia Veras Costa; Moraes Filho, Manoel Odorico de; Burbano, Rommel Mario Rodríguez; Guecheva, Temenouga Nikolova; Henriques, João Antonio Pegas; Pessoa, Cláudia do Ó (Elsevier, 2017)

Inhibition of Taq DNA Polymerase and Human Topoisomerase I by Resveratrol Derivatives

Chialva, Constanza Soledad; Avila, Héctor Gabriel; Pungitore, Carlos Rodolfo (Bentham Science Publishers, 2017-05)

Background: DNA polymerases and topoisomerases are proteins that play a vital part in DNA metabolism such as replication, transcription, recombination, and chromosome segregation during mitosis. For this reason, these ...

Inhibition of human topoisomerase i and activation of caspase-3 by aza-angucyclinones and arylaminopyrimido[4,5-c]isoquinoline-7,10-quinones

Autor desconocido (D.A. SPANDIDOS, 2012)

Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

Araque, Ileana; Ramírez, Javiera; Vergara, Rut; Mella, Jaime; Aránguiz, Pablo; Espinoza, Luis; Vera, Waleska; Montenegro, Iván; Salas, Cristian O.; Villena, Joan; Cuellar, Mauricio A. (MDPI, 2023-05)

In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A ...

Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors

Universidade Federal de São Carlos (UFSCar); Universidade Estadual Paulista (Unesp); Universidade de Brasília (UnB) (Springer, 2019-02-01)

Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF6 (1), ...

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