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Identification of Tmem10/Opalin as an Oligodendrocyte Enriched Gene Using Expression Profiling Combined with Genetic Cell Ablation
(WILEY-LISS, 2008-06-20)
Oligodendrocytes form an insulating multilamellar structure
of compact myelin around axons, which allows efficient
and rapid propagation of action potentials. However, little
is known about the molecular mechanisms ...
TMEM176A and TMEM176B are candidate regulators of inhibition of dendritic cell maturation and function after chronic spinal cord injury
(Mary Ann Liebert, 2020-02)
Inhibition of dendritic cell maturation and activation, together with abnormal functioning of cell-mediated immunity, has been reported in chronic spinal cord injury (SCI). The development of immune-based therapies could: ...
Impacto funcional de la inhibición farmacológica de Tmem176b en diferentes subpoblaciones de células dendríticas
(Udelar. FM, 2021)
Nuestro grupo ha reportado que la proteína Tmem176b es un canal/transportador iónico intracelular fuertemente expresado en células dendríticas (DCs), que bloquea la respuesta inmune anti-tumoral. Identificamos al compuesto ...
TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques
(Nature Publishing Group, 2019)
Oligodendrocyte precursor cells (OPCs) differentiate during postnatal development into myelin-forming oligodendrocytes, in a process distinguished by substantial changes in morphology and the onset of myelin gene expression. ...
Papel de tmem16a en la migración celular
(2016)
just stop doing your homework and put on your bathing suit to join your friends or finish
Tmem16 proteins: the long awaited calcium-activated chloride channels?
(ASSOC BRAS DIVULG CIENTIFICA, 2009)
Spectrum and Prevalence of FP/TMEM127 Gene Mutations in Pheochromocytomas and Paragangliomas
(AMER MEDICAL ASSOC, 2010)
Context Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest-derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene FP/TMEM127 in familial and ...
Germline mutations in TMEM127 confer susceptibility to pheochromocytoma
(NATURE PUBLISHING GROUP, 2010)
Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary(1). However, the molecular basis of the majority of these tumors is unknown(2). We identified the transmembrane-encoding ...
Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation
(Cell Press, 2019-05)
Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein ...
TRPC1 regulates calcium-activated chloride channels in salivary gland cells
(Wiley-liss, Div John Wiley & Sons Inc, 2015-11)
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion ...