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Paracrine regulation of megakaryo/thrombopoiesis by macrophages
(Elsevier Science Inc, 2011-07)
Objective: Megakaryo/thrombopoiesis is a complex process regulated by multiple signals provided by the bone marrow microenvironment. Because macrophages are relevant components of the bone marrow stroma and their activation ...
Anagrelide platelet-lowering effect is due to inhibition of both megakaryocyte maturation and proplatelet formation: Insight into potential mechanisms
(Wiley Blackwell Publishing, Inc, 2015-04)
Background and Objectives: Anagrelide represents a treatment option for essential thrombocythemia patients. It lowers platelet counts through inhibition of megakaryocyte maturation and polyploidization, although the basis ...
Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients
(Nature Publishing Group, 2016-03)
The Gray Platelet Syndrome (GPS) is a rare inherited bleeding disorder characterized by deficiency ofplatelet α-granules, macrothrombocytopenia and marrow fibrosis. The autosomal recessive form ofGPS is linked to loss of ...
ACCUMULATION OF 5-HYDROXYTRYPTAMINE BY AGING PLATELETS - STUDIES IN A MODEL OF SUPPRESSED THROMBOPOIESIS IN DOGS
(GEORG THIEME VERLAG KG, 1994)
Thrombocytopenia was induced in healthy, male mongrel dogs by intramuscular injection of a single dose of estradiol valerate (1 mg/kg). A steady, almost linear decay of the blood platelet count starting about day 6 ...
Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia
(Nature Publishing Group, 2019-12)
Mechanisms leading to low platelet count in immune thrombocytopenia (ITP) involves both decreased production and increased destruction of platelet. However, the contribution of these pathologic mechanisms to clinical outcome ...
Activation of toll‐like receptors 2 and 4 on CD 34 + cells increases human megakaryo/thrombopoiesis induced by thrombopoietin
(Wiley Blackwell Publishing, Inc, 2019-09)
Background: Platelet Toll‐like receptor (TLR)2/4 are key players in amplifying the host immune response; however, their role in human megakaryo/thrombopoiesis has not yet been defined. Objectives: We evaluated whether ...
Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis
(Taylor & Francis, 2010-12)
The aim of this study was to evaluate cell maturation and the platelet production capacity of the megakaryoblastic DAMI cell line, to characterize platelet-like particles produced and to investigate the mechanisms involved ...