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Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse
(Elsevier Science, 2011-01)
Background: Oxidoreductases of the thioredoxin family of proteins have been thoroughly studied in numerous cellular and animal models mimicking human diseases. Despite of their well documented role in various disease ...
Deciphering the role of multiple thioredoxin fold proteins of leptospirillum sp. in oxidative stress tolerance
(MDPI, 2020)
Thioredoxin fold proteins (TFPs) form a family of diverse proteins involved in thiol/disulfide exchange in cells from all domains of life. Leptospirillum spp. are bioleaching bacteria naturally exposed to extreme conditions ...
The Thioredoxins Protein System: a Key Target in Perinatal Asphyxia
(Cosmos Scholars, 2016-04)
Hypoxia during birth is one of the leading childhood mortality worldwide and results in many neurodisabled survivors. Several lines of evidence demonstrated that reactive oxygen species are the final step in the ...
Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia
(Elsevier Science, 2015-06)
Background Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide. ...
Long-Term Effects of Hypoxia-Reoxygenation on Thioredoxins in Rat Central Nervous System
(Bentham Science Publishers, 2020-01)
Oxidative stress induced by the oxidative pathway dysregulation following ischemia/reperfusion has been proposed as an important cause of neuronal death and brain damage. The proteins of the thioredoxin (Trx) family are ...
Inhibition of thioredoxin A1 from Corynebacterium pseudotuberculosis by polyanions and flavonoids
(2018-10-01)
In pathogens, the thioredoxin system forms part of the defense against oxidative stress and ensures the formation of the proper disulfide bonds to ensure protein function. In Corynebacterium pseudotuberculosis, the role ...
Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia–Ischemia
(Pergamon-Elsevier Science Ltd, 2019-11)
Thioredoxin family proteins are key modulators of cellular redox regulation and have been linked to several physiological functions, including the cellular response to hypoxia–ischemia. During perinatal hypoxia–ischemia ...
Degradation of PsbO by the Deg Protease HhoA Is Thioredoxin Dependent
(Public Library of Science, 2012-09)
The widely distributed members of the Deg/HtrA protease family play an important role in the proteolysis of misfolded and damaged proteins. Here we show that the Deg protease rHhoA is able to degrade PsbO, the extrinsic ...
A New Class of Thioredoxin‐Related Protein Able to Bind Iron-Sulfur Clusters
(Mary Ann Liebert, 2015-09)
AIMS:Members of the thioredoxin (Trx) protein family participate mainly in redox pathways and have not been associated with Fe/S binding, in contrast to some closely related glutaredoxins (Grxs). Cestode parasites possess ...
Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
(Bentham Science Publisher, 2019)
Abstract: Oxidative stress induced by the oxidative pathway dysregulation following ischemia/reperfusion has
been proposed as an important cause of neuronal death and brain damage. The proteins of the thioredoxin (Trx)
family ...