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Sequence diversity between class I MHC loci of African native and introduced Bos taurus cattle in Theileria parva endemic regions: in silico peptide binding prediction identifies distinct functional clusters
(Springer, 2016-05)
There is strong evidence that the immunity induced by live vaccination for control of the protozoan parasite Theileria parva is mediated by class I MHC-restricted CD8+ T cells directed against the schizont stage of the ...
Assessment and optimization of Theileria parva sporozoite full-length p67 antigen expression in mammalian cells
(Public Library of Science, 2017-08-11)
Delivery of various forms of recombinant Theileria parva sporozoite antigen (p67) has been shown to elicit antibody responses in cattle capable of providing protection against East Coast fever, the clinical disease caused ...
Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
(MDPI, 2018-04)
Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical ...
Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery
(Springer Heidelberg, 2014-12)
The binding of peptides to classical major histocompatibility complex (MHC) class I proteins is the single most selective step in antigen presentation. However, the peptide-binding specificity of cattle MHC (bovine leucocyte ...
Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever
(Frontiers Media Sa, 2018-10-03)
East Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria ...
Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle
(BioMed Central, 2014-04)
Peptide-major histocompatibility complex (p-MHC) class I tetramer complexes have facilitated the early detection and functional characterisation of epitope specific CD8+ cytotoxic T lymphocytes (CTL). Here, we report on ...
Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation
(2017-12-04)
The ticks Rhipicephalus appendiculatus and Rhipicephalus sanguineus are the main vectors of Theileria parva and Babesia spp. in cattle and dogs, respectively. Due to their impact in veterinary care and industry, improved ...
Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolates
(Elsevier Science, 2009-09)
Mini- and microsatellite sequences have proven to be excellent tools for the differentiation of strains and populations in several protozoan parasites due to their high variability. In the present work we have searched the ...
Estudio de la Miosina C de Plasmodium falciparum (PfMYO-C)
(Maestría en Ciencias Básicas BiomédicasUniversidad El BosqueFacultad de Medicina, 2011)
De las cinco especies de Plasmodium que causan la malaria, P. falciparum es la que produce la mayor mortalidad en el mundo, a pesar de los esfuerzos de los países endémicos por implementar diferentes estrategias para su ...
Identificación de hemoparásitos presentes en la herpetofauna de diferentes departamentos de Colombia
(Instituto de BiotecnologíaUniversidad Nacional de Colombia - Sede Bogotá, 2019-11-14)
Colombia es un país altamente diverso en flora y fauna, siendo el 4to país con mayor biodiversidad de reptiles en el mundo. Sin embargo, los estudios relacionados con parásitos sanguíneos que infectan animales ...