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Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization
(Wiley VCH Verlag, 2012-06)
Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we ...
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets
(2011)
The aim of this work was to study the effect of anti-TNF treatment on CD4+ Th1, Th17 and regulatory T cells (Tregs), together with CD8+ T cells and NK cells from rheumatoid arthritis (RA) patients. For this purpose, 18 RA ...
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
(Public Library Science, 2016)
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...
Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection
(Elsevier B.V., 2015-08-01)
The discovery of Th17 cells, along with many other Th cell subsets in the recent years, has expanded the Th1/Th2 paradigm that had persisted since its proposition by Mosmann in 1986. Defined by the characteristic expression ...
Th17 Cells in Viral Infections—Friend or Foe?
(MDPI, 2021)
Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection
(2008)
In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T
(Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, ...