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ABL inhibition activates TFEB and promotes cellular clearance in the lysosomal storage disorder Niemann-pick type C.LA INHIBICIÓN DE LA QUINASA ABL ACTIVA AL FACTOR TFEB Y PROMUEVE LA LIMPIEZA CELULAR EN LA ENFERMEDAD LISOSOMAL DE NIEMANN-PICK C
(2019)
Lysosomes are cellular organelles that play a fundamental role in cellular homeostasis because they are involved in different process such as: membrane repair, degradation and recycling of nutrients, macromolecules metabolism ...
La inhibición de la quinasa ABL al factor TFEB y promueve la limpieza celular en la enfermedad lisosomal de Niemann-Pick C
(2019)
Los lisosomas son organelos celulares que juegan un rol fundamental en la homeostasis celular al estar involucrados en procesos tales como: la reparación de la membrana plasmática, la degradación y el reciclaje de nutrientes, ...
Genistein activates transcription factor EB and corrects Niemann–Pick C phenotype
(MDPI, 2021)
Niemann-Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription ...
c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder
(Cell Press, 2020)
The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates ...