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Functional and phenotypical characteristics of testicular macrophages in experimental autoimmune orchitis
(John Wiley & Sons Ltd, 2008-01-22)
Testicular inflammation with compromised fertility can occur despite the fact that the testis is considered an immunoprivileged organ. Testicular macrophages have been described as cells with an immunosuppressor profile, ...
Tumour necrosis factor- released by testicular macrophages induces apoptosis of germ cells in autoimmune orchitis
(Oxford University Press, 2008-05)
BACKGROUND: Experimental autoimmune orchitis (EAO) is a model of chronic inflammation and infertility useful for studying testicular immune and germ cell (GC) interactions. In this model, EAO was induced in rats by ...
Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis
(Elsevier Ireland, 2006-06)
Experimental autoimmune orchitis (EAO) is an organ-specific model of autoimmunity characterized by an interstitial lymphomononuclear cell infiltrate as well as sloughing and apoptosis of germ cells. EAO was induced in adult ...
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue
(Wiley-Blackwell, 2014-03-01)
Nicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from ...
Local actions of melatonin in somatic cells of the testis
(MDPI AG, 2017-06)
The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a ...
β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility
(Elsevier Ireland, 2019-12)
Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients withidiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specificα- and ...
Inhibition of NOS-NO system prevents autoimmune orchitis development in rats: relevance of no released by testicular macrophages in germ cell apoptosis and testosterone secretion
(Public Library of Science, 2015-06)
Background: Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a model of ...
Pathomechanisms of autoimmune based testicular inflammation
(Frontiers Media, 2020-09)
Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune ...
Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein
(2021-01-01)
The role of cytokines in testicular function under normal conditions has not been completely understood. Here, we evaluated testicular macrophages (TM), steroidogenesis by Leydig cells (LC) and seminiferous tubules integrity ...
Cimetidine-induced Leydig cell apoptosis and reduced EG-VEGF (PK-1) immunoexpression in rats: evidence for the testicular vasculature atrophy
(Elsevier B. V., 2015)
The antiulcer drug cimetidine has shown to cause changes in the testicular microvasculature of adult rats. Since Leydig cells (LCs) produce the pro-angiogenic factor, EG-VEGF (endocrine gland-derived vascular endothelial ...