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The autoimmune response elicited by mouse hepatitis virus (mhv-a59) infection is modulated by liver tryptophan-2,3- dioxygenase (tdo)
(Elsevier Science, 2019-11)
In a previous work we demonstrated that inhibition of mouse indoleamine 2,3-dioxygenase (IDO) by methyltryptophan (MT) exacerbated the pathological actions of mouse hepatitis virus (MHV-A59) infection, suggesting that ...
Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase
(American Chemical Society, 2011-11-23)
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are the only two heme proteins that catalyze the oxidation reaction of tryptophan (Trp) to Nformylkynurenine.<br />While human IDO is able to oxidize both ...
Localizador 3D de Fuente Sonora Usando WSN3D Acoustic Source Localizer Using WSN
(Barranquilla, Universidad del Norte, 2018, 2019)
MPO Inhibitors Selected by Virtual Screening
(WILEY-BLACKWELL, 2011)
The hemeprotein myeloperoxidase (MPO) participates in innate immune defense through its ability to generate potent microbicidal oxidants. However, these oxidants are also key mediators of the tissue damage associated with ...
Pharmacophore Model of Cruzain Inhibitors
(WILEY-V C H VERLAG GMBH, 2009)
Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the most serious amongst the so-called neglected diseases in Latin America, specially in Brazil. So far there has been no effective treatment for the ...
Avaliação de impacto da estratégia TDO no controle da tuberculose em Pernambuco
(Universidade Federal de PerambucoUFPEBrasilPrograma de Pos Graduacao em Gestao e Economia da Saude, 2017)
Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi
(TAYLOR & FRANCIS LTD, 2010)
Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. The aim of this work was to assess whether NF and its derivative ...
Structural insights on the efficient catalysis of hydroperoxide reduction by Ohr: Crystallographic and molecular dynamics approaches
(Public Library Science, 2018)
Organic hydroperoxide resistance (Ohr) enzymes are highly efficient Cys-based peroxidases that play central roles in bacterial response to fatty acid hydroperoxides and peroxynitrite, two oxidants that are generated during ...