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Minicircle classes heterogeneity within the TcIII and TcIV discrete typing units of Trypanosoma cruzi
(Elsevier, 2017-07)
The taxon Trypanosoma cruzi, causative agent of Chagas disease, is composed of several discrete typing units (DTUs) named TcI-TcVI, and Tcbat. The history of the taxon T. cruzi is known, even though several controversial ...
Phylogenomics of Trypanosoma cruzi: Few evidence of TcI/TcII mosaicism in TcIII challenges the hypothesis of an ancient TcI/TcII hybridization
(Elsevier Science, 2017-06)
Phylogenetic relationships among major lineages of Trypanosoma cruzi are still debatable. Particularly, it is controversial the origin of two main lineages: TcIII and TcIV. Some authors proposed that these lineages have ...
Retrospective molecular integrated epidemiology of chagas disease in Colombia
American trypanosomiasis is a very complex zoonosis that is present throughout South America, Central America, and Mexico and continues to represent a serious threat to the health of countries in the region. The parasite ...
Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression
(2018)
Trypartosoma cruzi calreticulin (TcCalr, formerly known as TcCRT), upon binding to Complement (C) Cl and ficolins, inhibits the classical and lectin pathways and promotes infectivity. This virulence correlates with the ...
In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo
(Frontiers Media SA, 2018)
Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo
(Frontiers Media, 2018-02)
Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets ...
Chagas Cardiomyopathy Manifestations and Trypanosoma cruzi Genotypes Circulating in Chronic Chagasic Patients
(PUBLIC LIBRARY SCIENCE, 2010)
Chagas disease caused by Trypanosoma cruzi is a complex disease that is endemic and an important problem in public health in Latin America. The T. cruzi parasite is classified into six discrete taxonomic units (DTUs) based ...