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The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
(MDPI, 2022)
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, ...
TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties
(2020)
Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo ...
Denervation Drives YAP/TAZ Activation in Muscular Fibro/Adipogenic Progenitors
(2023-03)
Loss of motoneuron innervation (denervation) is a hallmark of neurodegeneration and aging of the skeletal muscle. Denervation induces fibrosis, a response attributed to the activation and expansion of resident fibro/adipogenic ...
A gente é o mundo que é a gente
(Centro de Estudos em Sustentabilidade da EAESP, 2009)
Faça humor não faça guerra
(Centro de Estudos em Sustentabilidade da EAESP, 2009)
Taz (zona autônoma temporária) como prática de liberdade e resistência política
(Universidade Federal de São Paulo (UNIFESP), 2016-08-06)
Phosphorylation regulates the bound structure of an intrinsically disordered protein: The p53-TAZ2 case
(Public Library of Science, 2016-01-07)
Disordered regions and Intrinsically Disordered Proteins (IDPs) are involved in critical cellular processes and may acquire a stable three-dimensional structure only upon binding to their partners. IDPs may follow a ...
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells
(2019)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with ...