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ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ESTROGEN-INDUCED AND OBSTRUCTIVE CHOLESTASIS, AND EFFECTS OF DIFFERENT BILE-ACIDS IN THE ISOLATED-PERFUSED RAT-LIVER
(MUNKSGAARD INT PUBL LTD, 1995)
Backgrounds/Aims: Canalicular membrane enzymes are normally released into bile by partially known processes. This study was undertaken to investigate whether hepatocellular cholestasis induced in rats by ethynylestradiol ...
Adaptive regulation of hepatic bile salt transport: Role of bile salt hydrophobicity and microtubule-dependent vesicular pathway
(MUNKSGAARD INT PUBL LTD, 1997)
Background/Aims: The hepatic transport of bile salts can be regulated by changes in bile salt pool size and/ or in the flux of bile salts through the liver, Prolonged bile salt pool depletion is associated with down-regulation ...
Effects of Japanese herbal medicine inchin-ko-to on endotoxin-induced cholestasis in the rat
(MEXICAN ASSOC HEPATOLOGY, 2009)
Background/Objective. Inchin-ko-to (ICKT) is an herbal medicine used in Japan to treat jaundice and liver fibrosis. We investigated the effect of oral ICKT supplementation on endotoxin-induced cholestasis in the rat. ...
ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ETHYNYLESTRADIOL-INDUCED CHOLESTASIS - EFFECTS OF URSODEOXYCHOLIC ACID ADMINISTRATION
(PERGAMON-ELSEVIER SCIENCE LTD, 1995)
Cholestasis is associated with a marked increase in the release of canalicular membrane enzymes into bile. This phenomenon has been related to an increased lability of these canalicular membrane integral proteins to the ...
Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis
(Pergamon-Elsevier Science Ltd, 2019-10)
Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease ...
Hepatic gene transfer of human aquaporin-1 improves bile salt secretory failure in rats with estrogen-induced cholestasis
(John Wiley & Sons Inc, 2016-08)
The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17α-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water ...
ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K
(Public Library Of Science, 2012-11)
Objective: The endogenous, cholestatic metabolite estradiol 17ß-d-glucuronide (E217G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether ...
Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
(Springer, 2017-06)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), ...
Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat
(W B SAUNDERS CO, 1998)
Increased biliary secretion of cholesterol and lipid vesicles (unilamellae and multilamellae) induced by diosgenin (D), a plant-derived steroid, has cytoprotective effects in the rat liver subjected to obstructive cholestasis. ...