Buscar
Mostrando ítems 1-10 de 607
Deletion of DNA sequences of using a polymerase chain reaction based approach
(Pontificia Universidad Católica de Valparaíso, 2006)
dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains
(American Society for Microbiology, 2016)
Para-Aminosalicylic acid (PAS) is a group 4 antituberculosis agent. It targets folate metabolism as shown in Fig. S1 in the supplemental material, which also summarizes the known mechanisms of resistance to this prodrug. ...
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
(Amer Soc Microbiology, 2021-11-01)
The routes of uptake and efflux should be considered when developing new drugs so that they can effectively address their intracellular targets. As a general rule, drugs appear to enter cells via protein carriers that ...
Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma
(Lippincott Williams & Wilkins, 2017-01-01)
Background: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. ...
Targeted deletion of centrin in leishmania braziliensis Using CRISPR-cas9-based editing
(Frontiers Media, 2022)
Channel Glass-based Detection of Human Short Insertion/ Deletion Polymorphisms by Tandem Hybridization
(2008)
The development and critical evaluation of newtechnologies for identifying genetic polymorphisms willrapidly accelerate the discovery and diagnosis of diseaserelatedgenes. We report a novel way for distinguishing anew class ...
DNA methylation and gene deletion analysisof brain metastases in melanoma patients identifies mutually exclusive molecular alterations
(Oxford University Press, 2014-06)
Background: The brain is a common target of metastases for melanoma patients. Little is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs). Unraveling these molecular alterations is a ...
Trypanosoma cruzi: Attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene
(Elsevier, 2007-12)
Calmodulin-ubiquitin (cub) is a single-copy gene of Trypanosoma cruzi, which encodes a 208 aminoacid polypeptide of unknown function, containing putative calcium-binding domains. After targeted deletion, a clone (TulCub8) ...