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Therapeutic targets in chagas disease
(2017-01-01)
Optimal pharmacotherapy occurs when we have selectivity and no toxicity. The discovery of specific pathways or enzymes that are vital forcell or parasite survival is also vital for the design of new specific, non-toxic ...
Computational Detection of MicroRNA Targets
(2022-01-01)
MicroRNAs (miRNAs) are small noncoding RNAs that are recognized as posttranscriptional regulators of gene expression. These molecules have been shown to play important roles in several cellular processes. MiRNAs act on ...
Measuring photogrammetric control targets in low contrast imagesMedição de alvos fotogramétricos em imagens com baixo contraste
(2018-04-01)
This paper presents an experimental assessment of photogrammetric targets and subpixel location techniques to be used with low contrast images such as images acquired by hyperspectral frame cameras. Eight different target ...
Prediction of drug targets in human pathogens
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The rapid emergence of resistant bacteria makes today's antibiotics more and more ineffective, consequently increasing the need for new pharmacological targets and novel classes of antibacterial drugs. The identification ...
Combining results from distinct microRNA target prediction tools enhances the performance of analyses
(2017-05-09)
Target prediction is generally the first step toward recognition of bona fide microRNA (miRNA)-target interactions in living cells. Several target prediction tools are now available, which use distinct criteria and stringency ...
Direct validation of NGcGM3 ganglioside as a new target for cancer immunotherapy
(Informa Healthcare, 2009-12)
OBJECTIVE: The target concept means not only an aberrant expression of a particular molecule in tumour tissues but also evidence of a clear therapeutic advantage, as a consequence of immune-intervention, in an antigen-positive ...
Up-regulation of microRNA targets correlates with symptom severity in Citrus sinensis plants infected with two different isolates of citrus psorosis virus
(Springer Verlag Berlín, 2019-11-27)
Main conclusion: miRNA targets from Citrus sinensis are predicted and validated using degradome data. They show an up-regulation upon infection with CPsV, with a positive correlation between target expression and symptom ...