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Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
The efficiency of multi-target drugs: A network approach
(Springer, 2020)
Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...
Injecting drug users who are (un)aware of their HIV serostatus: findings from the multi-center study AjUDE-Brasil II
(Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, 2006)
This study aimed to characterize the profiles of injecting drug users (IDUs) who were unaware of their HIV serostatus, given the importance of this information for prevention strategies, especially in this vulnerable ...
Injecting drug users who are (un)aware of their HIV serostatus: findings from the multi-center study AjUDE-Brasil IIUsuários de drogas injetáveis que (des)conhecem seu status sorológico para a infecção pelo HIV: achados do Projeto AjUDE-Brasil II
(Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, 2010)
Evolution of Reactive mPEG Polymers for the Conjugation of Peptides and Proteins
(Bentham Science Publishers, 2013-05)
The covalent attachment of methoxy-poly(ethylene glycol) (mPEG) is a well established strategy used to improve the pharmaceutical properties of several biomolecules. Since the pioneering work of Abuchovsky, PEGylation has ...
The variation of comonomers feeding profile to design the distribution of chains composition for the optimization of the mechanical properties in copolymer systems
(2009)
Context. Determining the parameters of massive stars is crucial to understand many processes in galaxies and the Universe, since these objects are important sources of ionization, chemical enrichment and momentum. 10m class ...
Identificación de moléculas pequeñas con potencial uso como chaperonas farmacológicas para la enzima humana N-acetilgalactosamina-6-sulfato sulfatasa (GALNS)
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - FarmacologíaDepartamento de FarmaciaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2022-08-21)
La mucopolisacaridosis IV A (MPS IVA) es una enfermedad autosómica recesiva causada por la deficiencia de la enzima N-acetilgalactosamina-6-sulfato sulfatasa (GALNS). La mayoría de mutaciones que afectan a esta enzima son ...