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Inhibition of beta-amyloid Aggregation of Ugni molinae Extracts
(Bentham Science Publishers, 2020)
The beta-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the ...
Point mutations affecting yeast prion propagation change the structure of its amyloid fibrils
(Elsevier Science, 2020-09)
We investigated the effect of the point substitutions in the N-terminal domain of the yeast prion protein Sup35 (Sup35NMp) on the structure of its amyloid fibrils. As the objects of the study, proteins with mutations that ...
The hyperforin derivative idn5706 occludes spatial memory impairments and neuropathological changes in a double transgenic alzheimers mouse model
(BENTHAM SCIENCE PUBL LTD, 2010)
The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, ...
Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis
(SPRINGER, 2008-11)
Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
Neuronal inclusions of alpha-synuclein contribute to the pathogenesis of Krabbe disease
(Wiley, 2014-01)
Demyelination is a major contributor to the general decay of neural functions in children with Krabbe disease. However, recent reports have indicated a significant involvement of neurons and axons in the neuropathology of ...
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease
(John Wiley & Sons Ltd, 2014-04)
Demyelination is a major contributor to the general decay of neural functions in children with Krabbe disease. However, recent reports have indicated a significant involvement of neurons and axons in the neuropathology of ...
The influence of both urea and 2,2,2
(Philadelphia, 2013-02-05)
The influence of external agents on proteins function and structure is essential
to elucidate the unfolding pathways and self-assemble properties. The knowledge
of the protein amyloid fibril formation process is important ...
Carbon Nanotubes Electrochemistry Allows the In Situ Evaluation of the Effect of β-Sheet Breakers on the Aggregation Process of β-Amyloid
(2012)
The inhibition of aggregation and disaggregation effect of a β-sheet breaker was evaluated by in situ electrochemistry of the Aβ 1-42 peptide. The exposition of 10tyr residue was followed using a carbon nanotubes modified ...