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How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway
(2022)
Synaptic transmission is a dynamic process that requires precise regulation. Early in life, we must be able to forge appropriate connections (add and remove) to control our behavior. Neurons must recognize appropriate ...
Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity
(Frontiers Media S.A., 2019-01)
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established ...
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...
Selective localization of phosphatidylcholine-derived signaling in detergent-resistant membranes from synaptic endings
(Elsevier Science, 2010-03)
Detergent-resistant membranes (DRMs) are a class of specialized microdomains that compartmentalize several signal transduction processes. In this work, DRMs were isolated from cerebral cortex synaptic endings (Syn) on the ...
Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
The mediodorsal nucleus of the thalamus (MD) is a rich source of afferents to the medial prefrontal cortex (mPFC). Dysfunctions in the thalamo-prefrontal connections can impair networks implicated in working memory, some ...
Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats
(2019-08)
Schizophrenia (SZ) is associated with changes in the structure and function of several brain areas. Several findings suggest that these impairments are related to a dysfunction in g-aminobutyric acid (GABA) neurotransmission ...
2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals
(Pergamon-Elsevier Science Ltd, 2017-08)
Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects ...