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Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function
(National Academy of Sciences, 2017-09)
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory ...
Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held
(Associação Brasileira de Divulgação Científica, 2009)
The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These ...
Lack of pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice
(Frontiers media SA, 2018)
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation. Although LTP has received considerable more attention, ...
On the mechanism of synaptic depression induced by camkiin, an endogenous inhibitor of camkii
(PUBLIC LIBRAY OF SCIENCE, 2012)
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
(2024)
Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells. This phenomenon is repetitive and produces a metabolic overload that increases ...
Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held
(Pergamon-Elsevier Science Ltd, 2020-07)
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. It has been reported that homomeric ASIC-1a channels are expressed in neurons of the medial nucleus of ...
Synaptic Homeostasis and Restructuring across the Sleep-Wake Cycle
(Aldo A Faisal, Imperial College London, UNITED KINGDOM, 2015-05-28)
Sleep is critical for hippocampus-dependent memory consolidation. However, the underlying
mechanisms of synaptic plasticity are poorly understood. The central controversy is on
whether long-term potentiation (LTP) takes ...
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
(2010)
Abstract
Background
Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ ...