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Promiscuous subunit interactions: A possible mechanism for the regulation of protein kinase CK2
(1998)
Protein kinase CK2 is a ubiquitous eukaryotic ser/thr protein kinase. The active holoenzyme is a heterotetrameric protein corn posed of catalytic (α and α') and regulatory (β) subunits that phosphorylates many different ...
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
(ROCKEFELLER UNIV PRESS, 2006-02)
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory ...
Folding kinetic pathway of phosphofructokinase-2 from Escherichia coli: A homodimeric enzyme with a complex domain organization
(2011)
Phosphofructokinase-2 is a 66 kD homodimer whose subunits are associated by means of a bimolecular domain, the β-clasp, which is linked to the larger portion of each subunit by a reentrant chain topology. To investigate ...
Echinococcus granulosus Antigen B Structure: Subunit Composition and Oligomeric States
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Antigen B (AgB) is the major protein secreted by the Echinococcus granulosus metacestode and is involved in key host-parasite interactions during infection. The full comprehension of AgB functions depends on ...
β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(National Academy of Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory β-subunits are one of the mechanisms responsible for creating BK channel diversity ...
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(Natl Acad Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory beta-subunits are one of the mechanisms responsible for creating BK channel diversity ...
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function
(American Society for Pharmacology and Experimental Therapeutics, 2017-03)
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding ...
The association of Na,K-ATPase subunits studied by circular dichroism, surface tension and dilatational elasticity
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
Different stoichiometries are observed between alpha and beta subunits of Na,K-ATPase that depend on the method employed to solubilize and purify the enzyme. It is not known whether this variability is due to loss of ...
Structural determinants for functional coupling between the β and α subunits in the Ca2+-activated K+ (BK) channel
(2006)
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory ...