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Tryptophan and aspartic acid residues present in the glycerophosphoryl diester phosphodiesterase (GDPD) domain of the Loxosceles laeta phospholipase D are essential for substrate recognition
(PERGAMON-ELSEVIER SCIENCE LTD, 2014)
It is known that the family of phospholipases D (PLD) from spiders of the genus Loxosceles, hydrolyze the substrates sphingomyelin and lisophosphatidylcholine, by their catalytic acid-base action which involves two histidines. ...
Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR
(Elsevier B.V., 2007-11-02)
The leader protease (Lb(pro)) of foot-and-mouth disease virus frees itself during translation from the viral polyprotein by cleavage between its own C terminus and the N terminus of the subsequent protein, VP4. Lb(pro) ...
Development of Conformation Independent Computational Models for the Early Recognition of Breast Cancer Resistance Protein substrates
(Hindawi Publishing Corporation, 2013-06)
ATP-Binding Cassette (ABC) efflux transporters are polyspecific members of the ABC superfamily that, acting as drug and metabolite carriers, provide a biochemical barrier against drug penetration and contribute to ...
Mapping the catalytic pocket of phospholipases A2 and C using a novel set of phosphatidylcholines
(Portland Press, 2000-03)
A set of radioiodinatable phosphatidylcholines (PCs) derivatized with the Bolton-Hunter reagent (BHPCs) was synthesized to probe the substrate recognition and activity of phospholipases. A common feature of this series is ...
Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450cam (CYP101A1)
(Academic Press Ltd - Elsevier Science Ltd, 2018-04)
Cytochrome P450cam (CYP101A1) catalyzes the stereospecific 5-exo hydroxylation of d-camphor by molecular oxygen. Previously, residual dipolar couplings measured for backbone amide 1H–15N correlations in both substrate-free ...