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Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone
Background: Quinones are reactive to proteins containing cysteine residues and the main protease
in Covid-19 contains an active site that includes Cys145. Embelin, a quinone natural product, is
known to have antiviral ...
Antiproliferative effect and ultrastructural alterations induced by 5-O-methylembelin on Trypanosoma cruzi
(Elsevier Gmbh, 2018-07)
Background: Embelin (EMB), obtained from Oxalis erythrorhiza Gillies ex Hooker et Arnott (Oxalidaceae), was reported against Trypanosoma cruzi and Leishmania spp. Additionally, antiprotozoan activity against Plasmodium ...
Estudio computacional del acoplamiento molecular de XIAP-BIR3 con ligantes de núcleo estructural alquílfenol
(Facultad de CienciasQuímica, 2018)
X-Linked Inhibitor of Apoptosis Protein (XIAP) acts as a cellular apoptosis inhibitor due to its high selectivity to caspase 9. This caspase activates caspases 3 and 7 in an autocatalytic way to produce cellular death. ...