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Endocannabinoid neuromodulation in the neostriatum decreases the GABAergic striato-nigral disinhibitory function and increases the nigro-collicular inhibitory pathway activity
(2020-08-01)
We previously reported the involvement of neostriato-nigral projections in the organisation of innate fear and panic attack-like responses organised by dorsal midbrain neurons, such as the periaqueductal grey matter and ...
D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
(Academic Press Inc Elsevier Science, 2009)
Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L‐DOPA in a mouse model of Parkinson's disease
(Wiley Blackwell Publishing, Inc, 2019-03)
Background and Purpose: L-DOPA-induced dyskinesia (LID) remains a major complication of L-DOPA therapy in Parkinson's disease. LID is believed to result from inhibition of substantia nigra reticulata (SNr) neurons by ...
The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice
(Pergamon-Elsevier Science Ltd, 2000-08)
Recent pathophysiological models of basal ganglia function in Parkinson's disease predict that specific neurochemical changes in the indirect pathway would follow the lack of stimulation of D2 dopamine receptors. Post ...
Análisis de los efectos de la eliminación del gen PTEN en las neuronas dopaminérgicas del cerebro medio del ratón
(07/12/2010)
ABSTRACT: The widespread distribution of the tumor suppressor pten in the nervous system suggests it has a role in a broad range of brain functions. Pten negatively regulates the signaling pathways initiated by protein ...