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DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
(2021-04-15)
For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome ...
Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks
(2003)
The present report deals with the functional relationships among protein complexes which, when mutated, are responsible for four human syndromes displaying cancer proneness, and whose cells are deficient in DNA double-strand ...
Subtelomeric I-scei-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Research Foundation, 2016)
Subtelomeric I-scel-mediated Double-strand Breaks Are Repaired By Homologous Recombination In Trypanosoma Cruzi
(Frontiers Media SALausanne, 2016)
Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
(2020)
Hereditary mutations in polynucleotide kinasephosphatase
(PNKP) result in a spectrum of neurological
pathologies ranging from neurodevelopmental
dysfunction in microcephaly with early onset
seizures (MCSZ) to ...
Epigenetic Regulation Of Dna Repair Machinery In Helicobacter Pylori-induced Gastric Carcinogenesis
(BAISHIDENG PUBLISHING GROUP INCPLEASANTON, 2015)
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians
(Elsevier Sci Ireland LtdClareIrlanda, 2002)