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Assessment of the stereoselective fungal biotransformation of albendazole and its analysis by HPLC in polar organic mode
(ELSEVIER SCIENCE BVAMSTERDAM, 2013-08-02)
A high-performance liquid chromatographic method using polar organic mode was developed to analyze albendazole (ABZ), albendazole sulfone (ABZSO(2)) and the chiral and active metabolite albendazole sulfoxide (ABZSOX, ...
Metabolism of aromatic hydrocarbons by the filamentous fungus Cyclothyrium sp.
(Pergamon-elsevier Science LtdOxfordInglaterra, 2004)
Enantioselective metabolism of hydroxychloroquine employing rats and mice hepatic microsomes
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2009)
Hydroxychloroquine (HCQ) is an important chiral drug used, mainly, in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria, and whose pharmacokinetic and pharmacodynamic properties look to be ...
Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients
(SPRINGER, 2011)
Purpose This study investigated the influence of gestational diabetes mellitus on the kinetic disposition and stereoselective metabolism of labetalol administered intravenously or orally. Methods Thirty hypertensive women ...
Comparative bioavailability study with two pantoprazole delayed-released tablet formulations administered with and without food in healthy subjects
(Ecv-editio Cantor Verlag Medizin NaturwissenschaftenAulendorfAlemanha, 2008)
Stereoselective Analysis of Labetalol in Human Plasma by LC-MS/MS: Application to Pharmacokinetics
(WILEY-LISS, 2009)
Labetalol is clinically available as a mixture of two racemates (four stereoisomers). The stereoisomer (R,R) has as main activity the beta(1)-antagonism and the stereoisomer (S,R) is highly selective for the alpha(1) ...
Risk assessment of the chiral pesticide fenamiphos in a human model: Cytochrome P450 phenotyping and inhibition studies
(2020-12-01)
Fenamiphos (FS) is a chiral organophosphate pesticide that is used to control nematodes in several crops. Enantioselective differences may be observed in FS activity, bioaccumulation, metabolism, and toxicity. Humans may ...
Influence of Quinidine, Cimetidine, and Ketoconazole on the Enantioselective Pharmacokinetics and Metabolism of Metoprolol in Rats
(WILEY-LISS, 2009)
Metoprolol is a beta-blocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. ...
Reduction of enantioselectivity in the kinetic disposition and metabolism of verapamil in rats exposed to toluene
(Canadian Science Publishing, Nrc Research Press, 2008-05-01)
Toluene and verapamil are subject to extensive oxidative metabolism mediated by CYP enzymes, and their interaction can be stereoselective. In the present study we investigated the influence of toluene inhalation on the ...
Reduction of enantioselectivity in the kinetic disposition and metabolism of verapamil in rats exposed to toluene
(Canadian Science Publishing, Nrc Research Press, 2008-05-01)
Toluene and verapamil are subject to extensive oxidative metabolism mediated by CYP enzymes, and their interaction can be stereoselective. In the present study we investigated the influence of toluene inhalation on the ...