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Physical factors affecting plasmid DNA compaction in stearylamine-containing nanoemulsions intended for gene delivery
(2012-06-13)
Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material ...
Physical factors affecting plasmid DNA compaction in stearylamine-containing nanoemulsions intended for gene delivery
(2012-06-13)
Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material ...
Piroxicam encapsulated in liposomes: Characterization and in vivo evaluation of topical anti-inflammatory effect
(Marcel Dekker Inc, 1999-01-01)
Liposomes of soya phosphatidylcholine, cholesterol, and stearylamine (molar ratio 6/3/1) and 0.1% alpha-tocopherol were prepared by the extrusion of multilamellar vesicles through 0.2-mu m polycarbonate membrane. Liposomes ...
Piroxicam encapsulated in liposomes: Characterization and in vivo evaluation of topical anti-inflammatory effect
(Marcel Dekker Inc, 1999-01-01)
Liposomes of soya phosphatidylcholine, cholesterol, and stearylamine (molar ratio 6/3/1) and 0.1% alpha-tocopherol were prepared by the extrusion of multilamellar vesicles through 0.2-mu m polycarbonate membrane. Liposomes ...
Produção e avaliação de nanoemulsão catiônica como possível vetor não-viral para pIRES2-EGFP
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Ciências FarmacêuticasBioanálises e Medicamentos, 2013-03-19)
Gene therapy is based on the transfer of exogenous genetic material into cells or tissues in order to correct, supplement or silencing a particular gene. To achieve this goal, efficient vehicles, viral or non-viral, should ...
Diacetylenic lipids in the design of stable lipopolymers able to complex and protect plasmid DNA
(Public Library of Science, 2017-10)
Different viral and non-viral vectors have been designed to allow the delivery of nucleic acids in gene therapy. In general, non-viral vectors have been associated with increased safety for in vivo use; however, issues ...