Buscar
Mostrando ítems 1-10 de 109
Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells
(Elsevier, 2020)
In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
Src-family kinase inhibitors block early steps of caveolin-1-enhanced lungmetastasis by melanoma cells
(2020)
In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling
(Elsevier Inc, 2010-03)
The cytokine prolactin (PRL) plays important roles in the proliferation and differentiation of the mammary gland and it has been implicated in tumorigenesis. The prolactin receptor (PRLR) is devoid of catalytic activity ...
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease
(Taylor and Francis, 2016)
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...
Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2005)
Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment
(Frontiers Media Sa, 2016)
Histoplasma capsulatum var. capsulatum is a dimorphic fungus that causes histoplasmosis, a human systemic mycosis with worldwide distribution. In the present work, we demonstrate that H. capsulatum yeasts are able to induce ...
Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2003)
Differentiation of C2C12 myoblasts is critically regulated by FAK signaling
(Amer Physiological SocBethesdaEUA, 2005)