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Presence, processing, and localization of mouse ADAM15 during sperm maturation and the role of its disintegrin domain during sperm egg binding
(2008)
Successful fertilization requires gametes to complete several stages, beginning with maturation and transport along the male and femalereproductive tracts and ending with the interaction between the sperm and the egg. This ...
Structure and function of Caltrin (calcium transport inhibitor) proteins
(Sage Publications Ltd, 2017-12)
Caltrin (calcium transport inhibitor) is a family of small and basic proteins of the mammalian seminal plasma which bind to sperm cells during ejaculation and inhibit the extracellular Ca2+ uptake, preventing the premature ...
ESCRT (endosomal sorting complex required for transport) machinery is essential for acrosomal exocytosis in human sperm
(Society for the Study of Reproduction, 2015-11)
The sperm acrosome reaction is a unique, regulated exocytosis characterized by the secretion of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal and plasma membranes. In ...
SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity
(BioScientifica, 2012-03)
Serine protease inhibitor Kazal-type (SPINK3)/P12/PSTI-II is a small secretory protein from mouse seminal vesicle which contains a KAZAL domain and shows calcium (Ca 2+)-transport inhibitory (caltrin) activity. This molecule ...
Cdc42 localized in the CatSper signaling complex regulates cAMP‐dependent pathways in mouse sperm
(Federation of American Societies for Experimental Biology, 2021-07)
Sperm acquire the ability to fertilize in a process called capacitation and undergo hyperactivation, a change in the motility pattern, which depends on Ca2+ transport by CatSper channels. CatSper is essential for fertilization ...
Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation
(Wiley Periodicals Inc., 2017-06)
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation. It is well established that HCO3 − is essential for capacitation ...
CFTR/ENaC-dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC
(American Society for Biochemistry and Molecular Biology, 2018-06)
To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation. From a molecular point of view, the HCO3-dependent activation ...
Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines
(Nature, 2020-09)
Previously we demonstrated that multidrug resistance-associated protein 4 transporter (MRP4) mediates cAMP efflux in bovine spermatozoa and that extracellular cAMP (ecAMP) triggers events associated to capacitation. Here, ...