Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly ...

The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...

As a part of preformulation studies, the aim of this work was to examine the solubility and stability of a series of 50 -O-carbonates of lamivudine with proven antihuman immunodeficiency virus activity. Solubility studies ...

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a mechanochemical method (neat and liquid-assisted ...

Rifaximin, an oral antimicrobial drug, is marketed as 200-mg tablets. The daily dose ranges from 600 mg (1 tablet 3 times a day) to 800 mg (2 tablets twice a day). It is used for a wide range of ages, from adults to children, ...

Objective  The aim of this study is to verify the influence of three pigment incorporation methods (conventional, mechanical, and industrial) on the sorption and solubility of the MDX4-4210 and A-2186 silicones. Materials ...