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Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(2010-01-01)
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first ...
Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000
(TAYLOR & FRANCIS INCPHILADELPHIA, 2012)
The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407). Consequently, the objective of this study was to evaluate ...
On the solubility of proteins as a function of pH: Mathematical development and application
(ELSEVIER SCIENCE BV, 2011)
Thermodynamic relations between the solubility of a protein and the solution pH are presented in this work. The hypotheses behind the development are that the protein chemical potential in liquid phase can be described by ...
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
(Universidade de São Paulo (USP), Conjunto Quimicas, 2014)
The Preparation of Ternary Solid Dispersions of an Herbal Drug via Spray Drying of Liquid Feed
(TAYLOR & FRANCIS INC, 2010)
The present study aimed the preparation and characterization of ternary solid dispersions by direct spray drying of a liquid suspension containing curcumin, a solubility enhancer and a drying aid. The experiments followed ...