Buscar
Mostrando ítems 1-10 de 1241
Metronidazole-loaded polyethyleneimine and chitosan-based liquid crystalline system for treatment of staphylococcal skin infections
(2018-01-01)
Staphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It is also a dangerous pathogen that can cause serious and even lethal skin infections. The topical administration of metronidazole ...
Solid lipid nanoparticles optimized by 22 factorial design for skin administration: Cytotoxicity in NIH3T3 fibroblasts
(2018-11-01)
The present study focuses on the characterization of the cytotoxic profile on NIH3T3 mouse embryonic fibroblasts of solid lipid nanoparticles (SLN) optimized by a 22 full factorial design for skin administration. To build ...
Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review
(Bentham Science Publ Ltd, 2021-01-01)
Administration of substances through the skin represents a promising alternative, in relation to other drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug ...
Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface
(ELSEVIER SCIENCE INC, 2013-07-01)
A transient percutaneous drug absorption model was solved in two dimensions. Clearance of the topically-applied pharmaceutical occured at the skin-capillary boundary. Timolol penetration profiles in the dermal tissue were ...
Pharmacokinetics and skin concentrations of lincomycin after intravenous and oral administration to cats
(South African Veterinary Association, 2013-10)
The aim of the present study was to describe the plasma pharmacokinetic profile and skin concentrations of lincomycin after intravenous administration of a 15% solution and oral administration of 300 mg tablets at a dosing ...
Evaluation of skin absorption of drugs from topical and transdermal formulations
(Univ Sao Paulo, Conjunto Quimicas, 2016-07-01)
The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds ...
Nanodrug Delivery Systems for Dermal and Transdermal Photosensitizer Drugs
(2017-03-29)
Skin is the largest organ in the human body and functions as a protective barrier. Molecules can penetrate the skin by three main routes: (1) intracellular (across the corneocytes), (2) intercellular lipids, and (3) ...
Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays
(2017-08-24)
Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of ...