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Identification of inhibitors to Trypanosoma cruzi Sirtuins based on compounds developed to human enzymes
(MDPI, 2020)
Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, a↵ecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to ...
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
(Cognizant Communication Corporation, 2020)
Chemical constituents of Anacardium occidentale as inhibitors of Trypanosoma cruzi Sirtuins
(MDPI, 2019)
Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets ...
Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets
(Public Library of Science, 2018)
Potential modulation of sirtuins by oxidative stress
(Hindawi Publishing Corporation, 2016)
Sirtuins are a conserved family of NAD-dependent protein deacylases. Initially proposed as histone deacetylases, it is now known that they act on a variety of proteins including transcription factors and metabolic enzymes, ...
Characterization of Trypanosoma cruzi Sirtuins as possible drug targets for Chagas disease
(ASM, 2015)
Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent ...
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease
(American Society for Microbiology, 2015)
Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent ...