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Enfermedad del coronavirus(covid-19) y las sirtuinas
(Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Ciencia y Tecnología., 2020-06-16)
Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del ...
Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6
(Wiley Blackwell Publishing, Inc, 2018-01)
Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus (DM) and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease ...
SIRT6 is required for normal retinal function
(Public Library Of Science, 2014-06)
The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding ...
SIRT1 Deacetylase Activity and the Maintenance of Protein Homeostasis in Response to Stress: An Overview
(Bentham Science Publ Ltd, 2011-02-01)
The present review intends to summarize the, yet preliminary, but very important emerging data underlining the functions exerted by the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase SIRT1 on protein ...
SIRT1 Deacetylase Activity and the Maintenance of Protein Homeostasis in Response to Stress: An Overview
(Bentham Science Publ Ltd, 2011-02-01)
The present review intends to summarize the, yet preliminary, but very important emerging data underlining the functions exerted by the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase SIRT1 on protein ...
SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: An overview
(2011-02-01)
The present review intends to summarize the, yet preliminary, but very important emerging data underlining the functions exerted by the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase SIRT1 on protein ...
SIRT1-dependent effects of resveratrol and grape juice in an in vitro model of preeclampsia
(2020-11-01)
Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy that is partly responsible for both maternal and fetal morbidity and mortality levels worldwide. It has been recently discovered that sirtuin-1 (SIRT1) ...
Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer
(Elsevier Inc, 2015-10)
Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether point mutations are selected ...
Theobromine Increases Nad(+)/sirt-1 Activity And Protects The Kidney Under Diabetic Conditions
(AMER PHYSIOLOGICAL SOCBETHESDA, 2015)