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Fast computational mutation-response scanning of proteins
(PeerJ, 2021-04-21)
Studying the effect of perturbations on protein structure is a basic approach in protein research. Important problems, such as predicting pathological mutations and understanding patterns of structural evolution, have been ...
nfxB as a Novel Target for Analysis of Mutation Spectra in Pseudomonas aeruginosa
(Public Library Science, 2013-06-07)
nfxB encodes a negative regulator of the mexCD-oprJ genes for drug efflux in the opportunistic pathogen Pseudomonas aeruginosa. Inactivating mutations in this transcriptional regulator constitute one of the main mechanisms ...
A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance
(BioMed Central, 2017)
BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
Mutation in Honeybees 2. Average Rate of Mutation Based on Seven Genes for Eye Colour
(1983-01-01)
The average numbers of ommatidia in the eyes of workers was 3826 and in the eyes of males 7082. Somatic mutations from recessive to dominant were detected in 7 genes, some reported in this paper, some in an earlier ...
Antithrombin deficiency in Brazilian patients with venous thrombosis molecular characterization of a single splice site mutation, an insertion and a de novo point mutation
(Pergamon-elsevier Science LtdOxfordInglaterra, 2001)
Label-free oligonucleotide-based SPR biosensor for the detection of the gene mutation causing prothrombin-related thrombophilia
(MDPI, 2020)
Prothrombin-related thrombophilia is a genetic disorder produced by a substitution of a single DNA base pair, replacing guanine with adenine, and is detected mainly by polymerase chain reaction (PCR). A suitable alternative ...