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Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, in vivo and in silico schistosomicidal activity
(2021-01-01)
Lignan dinitrohinokinin displays important biological activities, which led to the preparation of its poly-ε-caprolactone nanoparticles. Kinetics analysis revealed initially slow drug release followed by a prolonged, ...
Schistosoma mansoni: In vitro schistosomicidal activity of piplartine
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Schistosomiasis is one of the world`s greatly neglected tropical diseases, and its control is largely dependent on a single drug, praziquantel. Here, we report the in vitro effect of piplartine, an amide isolated from Piper ...
Schistosoma mansoni: In vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Schistosomiasis is one of the most important parasitic infections in humans that occur in many tropical and subtropical countries. Currently, the control of schistosomiasis rests with a single drug, praziquantel, which is ...
Schistosomicidal and trypanocidal structure-activity relationships for (+/-)-licarin A and its (-)- and (+)-enantiomers
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
(+/-)-Licarin A (1) was obtained by oxidative coupling, and its enantiomers, (-)-licarin A (2) and (+)-licarin A (3), were resolved by chiral HPLC. Schistosomicidal and trypanocidal activities of these compounds were ...
In Vitro Schistosomicidal Activity of Balsaminol F and Karavilagenin C
(GEORG THIEME VERLAG KGSTUTTGART, 2012)
Five cucurbitane-type triterpenes (1-5), previously isolated from the African medicinal plant Momordica balsamina, along with five ester derivatives (6-10) of karavilagenin C (2), were evaluated for their potential ...
Activity of the artemether in experimental schistosomiasis mansoni
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2020)
Schistosomicidal evaluation of flavonoids from two species of Styrax against Schistosoma mansoni adult worms
(INFORMA HEALTHCARELONDON, 2012)
Context: Schistosomiasis is a major health problem worldwide. Thus, the search for new schistosomicidal agents from natural sources can provide prototypes for drug discovery. Objective: The present study investigated the ...
Fungal Transformation and Schistosomicidal Effects of Pimaradienoic Acid
(WILEY-V C H VERLAG GMBHWEINHEIM, 2012)
The schistosomicidal effects of pimaradienoic acid (PA) and two derivatives, obtained by fungal transformation in the presence of Aspergillus ochraceus, were investigated. PA was the only compound with antischistosomal ...
In vitro schistosomicidal activity of the lignan ( )-6,60-dinitrohinokinin (dnhk) loaded into poly(lactic-co-glycolic acid) nanoparticles against schistosoma mansoni
(2017-01-01)
Context: ( )-6,60-Dinitrohinokinin (DNHK) display remarkable antiparasitic activity and was, therefore, incorporated into a nanoparticle formulation. Objective: Incorporation of DNHK in poly lactic-co-glycolic acid (PLGA) ...