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A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis
(Nature Publishing Group, 2019-12)
Acetyl-CoA carboxylases (ACCs) are enzyme complexes generally composed of three catalytic domains and distributed in all organisms. In prokaryotes and plastids of most plants, these domains are encoded in distinct subunits ...
Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii
(Amer Soc Microbiology, 2015)
Streptomyces leeuwenhoekii, isolated from the hyperarid Atacama Desert, produces the new ansamycin-like compounds chaxamycins A to D, which possess potent antibacterial activity and moderate antiproliferative activity. We ...
Aislamiento de mutantes rpoB S531L resistentes a rifampicina en Mycobacterium tuberculosis H37Rv ATCC 25618 e identificación de biomarcadores de adaptación
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - MicrobiologíaInstituto de Biotecnología (IBUN)Facultad de CienciasBogotáUniversidad Nacional de Colombia - Sede Bogotá, 2021)
La TB multirresistente es causada por Mycobacterium tuberculosis (MTB) resistente a rifampicina e isoniazida y constituye un grave problema de salud pública en países emergentes. Puesto que el fitness del agente patógeno ...