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Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon
(PUBLIC LIBRARY SCIENCE, 2016)
Synaptic vesicles (SVs) fuse with the plasma membrane at a precise location called the pre synaptic active zone (AZ). This fusion is coordinated by proteins embedded within a cytoskeletal matrix assembled at the AZ (CAZ). ...
Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held
(Associação Brasileira de Divulgação Científica, 2009)
The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These ...
Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction
(Wiley-liss, Div John Wiley & Sons Inc, 2017-09)
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells. We combined fluorescent FM ...
Role of Rab27 in synaptic transmission at the squid giant synapse
(NATL ACAD SCIENCES, 2008)
Small GTPase Rab is a member of a large family of Ras-related proteins, highly conserved in eukaryotic cells, and thought to regulate specific type(s) and/or specific step(s) in intracellular membrane trafficking. Given ...
Wnt - 7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons
(2008)
Wnt signaling is essential for neuronal development and the maintenance of the developing nervous system. Recent studies indicated that Wnt signaling modulates long term potentiation in adult hippocampal slices. We report ...
Ca2+-independent and voltage-dependent exocytosis in mouse chromaffin cells
(Wiley Blackwell Publishing, Inc, 2020-04)
Aim: It is widely accepted that the exocytosis of synaptic and secretory vesicles is triggered by Ca2+ entry through voltage-dependent Ca2+ channels. However, there is evidence of an alternative mode of exocytosis induced ...
The immediately releasable pool of mouse chromaffin cell vesicles is coupled to P/Q-type calcium channels via the synaptic protein interaction site
(Public Library Science, 2013-01)
It is generally accepted that the immediately releasable pool is a group of readily releasable vesicles that are closely associated with voltage dependent Ca(2+) channels. We have previously shown that exocytosis of this ...
Interaction between facilitation and depression at a large CNS synapse reveals mechanisms of short-term plasticity
(Society for Neuroscience, 2010-02)
The two fundamental forms of short-term plasticity, short-term depression and facilitation, coexist at most synapses, but little is known about their interaction. Here, we studied the interplay between short-term depression ...
Participacão do transporte de acetilcolina, do cálcio intracelular e do colesterol de membrana no ciclo de vesiculas sinapticas em juncãoneuromuscular
(Universidade Federal de Minas GeraisUFMG, 2010-01-29)
Synaptic vesicles recycling is essential for the maintenance ofneurotransmission by preventing the collapse of synaptic function. In this work, three important aspects of the synaptic vesicle cycle were investigated in ...