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A search in rat brain cortex synaptic vesicles for endogenous ligands for kainic acid receptors
(1982)
Conditions were found for stabilizing rat brain cortex kainic acid (KA) receptors. Such receptors had the same Hill number (about 0.6) for KA and for glutamate. The receptors were then used as detectors for endogenous ...
Endogenous ligands for the quisqualate receptor: presence in rat brain cortex synaptic vesicles
(1988)
The presence in highly purified rat brain cortex synaptic vesicles of endogenous ligands for rat brain quisqualate receptors was investigated. The vesicles were extracted, and their contents fractionated by high voltage ...
Amplification of neuromuscular transmission by methylprednisolone involves activation of presynaptic facilitatory adenosine A(2A) receptors and redistribution of synaptic vesicles
(Elsevier B.V., 2015-02-01)
The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic ...
c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases
(2023)
Our ability to learn and remember depends on the active formation, remodeling, and elimination of synapses. Thus, the development and growth of synapses as well as their weakening and elimination are essential for neuronal ...
Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes
(International Society for Neurochemistry, 2007)
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB
are essential regulators of synaptic function in the adult CNS. A
TrkB-mediated effect at excitatory synapses is enhancement of
NMDA receptor (NMDA-R)-mediated ...
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
(Elsevier Ireland Ltd, 2019)
Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft
(2018)
GABA is a widely distributed inhibitory neurotransmitter. GABA-A receptors are hetero-pentameric channels assembled in multiple combinations from 19 available subunits; this diversity mediates phasic and tonic inhibitory ...
Topological regulation of synaptic AMPA receptor expression by the RNA-Binding protein CPEB3
(Elsevier B.V., 2016-09)
Synaptic receptors gate the neuronal response to incoming signals, but they are not homogeneously distributed on dendrites. A spatially defined receptor distribution can preferentially amplify certain synaptic inputs, ...
Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function
(National Academy of Sciences, 2017-09)
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory ...