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Cochlear hair cells: The sound-sensing machines
(Elsevier, 2015-08-31)
The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In ...
Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs
(John Wiley & Sons Inc, 2009-12)
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic ...
Enhancement of the medial olivocochlear system prevents hidden hearing loss
(Society for Neuroscience, 2018-08)
Cochlear synaptopathy produced by exposure to noise levels that cause only transient auditory threshold elevations is a condition that affects many people and is believed to contribute to poor speech discrimination in noisy ...
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
(Nature Publishing Group, 2015-02)
Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. ...
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
(Sociedad de Biología de Chile, 2011)
Corrigendum to “Neuromuscular synapse degeneration without muscle function loss in the diaphragm of a murine model for Huntington's Disease"
(2018-09-01)
The authors regret that the trace in Fig. 6H was the same as from Fig. 6I. We have inserted the correct trace in Fig. 6H. The authors would like to apologise for any inconvenience caused.
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior
(2019)
Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly uncover these mechanisms, we studied the 22q11.2 syndrome, a recurrent copy number variant, which is the highest schizophrenia genetic risk ...
Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-beta Oligomers
(Amer Soc Biochemistry Molecular Biology Inc, 2011-02-04)
Soluble oligomers of the amyloid-beta peptide (A beta Os) accumulate in the brains of Alzheimer disease (AD) patients and are implicated in synapse failure and early memory loss in AD. A beta Os have been shown to impact ...
Neuromuscular synapse degeneration without muscle function loss in the diaphragm of a murine model for Huntington's Disease
(2018-06-01)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by chorea, incoordination and psychiatric and behavioral symptoms. The leading cause of death in HD patients is aspiration pneumonia, ...