Several studies suggest that the assembly of mitochondrial respiratory complexes into structures known as supercomplexes (SCs) may increase the efficiency of the electron transport chain, reducing the rate of production ...

We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and ...

Espécies reativas de oxigênio (ERO) são moléculas químicas derivadas do O2 que são mais reativas que o mesmo. A cadeia transportadora de elétrons, localizada na mitocôndria, é uma das principais fontes de produção dessas ...

Several biological activities depend on iron–sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We ...

Cytochrome c (CYTc) is a soluble redox-active heme protein that transfers electrons from Complex III to Complex IV in the cyanide-sensitive mitochondrial respiratory pathway. CYTc biogenesis is a complex process that ...

Mitochondria display a central role in cellular activity, being essential for energetic metabolism, Ca2+ homeostasis and cell signalling. The brain is one of the organs with the highest oxygen consumption of the human body, ...

Glycolysis generates methylglyoxal (MGO) as an unavoidable, cytotoxic by-product in plant cells. MGO scavenging is performed by the glyoxalase system, which produces D-lactate as an end product. D-Lactate dehydrogenase ...

Acidophilic organisms, such as Acidithiobacillus ferrooxidans, possess high-level resistance to copper and other metals. A. ferrooxidans contains canonical copper resistance determinants present in other bacteria, such ...