Response surface designs are usually described as if the treatments have been completely randomized to the experimental units. However, in practice there is often a structure to the units, implying the need for blocking. ...

For purpose of enhancing the seismic performance of civil structures, external passive energy dissipation systems have been extensively used. Usually, the energy dissipation system is provided once the structure has been ...

Inverse methods are mathematical techniques by which the unknown input of a system is determined from a known or desired output. In this article, a new inverse method for the reverse design of deformable structures is ...

Drug resistance is a common concern for the development of novel antiviral, antimicrobial and anticancer therapies. To overcome this problem, several strategies have been developed, many of which involving the theme of ...

Seismic design relies on inelastic deformations through hysteretic behavior. However, this translates into damage on structural elements, permanent system deformations following an earthquake, and possibly high cost for ...

Design education faces new challenges due to the growing globalization, dynamism of markets, the development of technology and high levels of complexity in various systems. The Circular Economy has been proposed as a ...

A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design ...

Drug discovery has moved toward more rational strategies based on our increasing understanding of the fundamental principles of protein-ligand interactions. Structure( SBDD) and ligand-based drug design (LBDD) approaches ...