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Inhibition of L-Type Ca 2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons
(Society for Neuroscience, 2017-03)
Loss of dopaminergic (DA) neurons leads to Parkinson’s disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood. We demonstrate that TRPC1 regulates the L-type Ca2 channel that ...
STIM and Orai proteins: players in sexual differences in hypertension-associated vascular dysfunction?
(PORTLAND PRESS LTD, 2010)
Sex-associated differences in hypertension have been observed repeatedly in epidemiological studies; however, the mechanisms conferring vascular protection to females are not totally elucidated. Sex-related differences in ...
STIM 1/Orai 1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats
(PORTLAND PRESS LTDLONDON, 2012)
Sex differences in Ca2+-dependent signalling and homoeostasis in the vasculature of hypertensive rats are well characterized. However, sex-related differences in SOCE (store-operated Ca2+ entry) have been minimally ...
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells
(Wiley, 2017)
Abstract: Depletion of Ca2+ stores activates store-operated channels (SOCs), which mediate Ca2+ entry pathways that regulate cellular processes such as contraction, proliferation and gene expression. In vascular smooth ...
Satisfacción en los cuidadores primarios de los pacientes con parálisis cerebral posterior al tratamiento con VitalStim
(Universidad Autónoma del Estado de México, 2016)
Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells
(Taylor & Francis, 2017-03)
Ca2+-permeable store-operated channels (SOCs) mediate Ca2+ entry pathways which are involved in many cellular functions such as contraction, growth, and proliferation. Prototypical SOCs are formed of Orai1 proteins and are ...
Increased Activation of Stromal Interaction Molecule-1/Orai-1 in Aorta From Hypertensive Rats A Novel Insight Into Vascular Dysfunction
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Disturbances in the regulation of cytosolic calcium (Ca(2+)) concentration play a key role in the vascular dysfunction associated with arterial hypertension. Stromal interaction molecules (STIMs) and Orai proteins represent ...
The polyphenol ellagic acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators
(Elsevier, 2020)
Ellagic acid, a naturally occurring phenol found in a variety of fruits and nuts has been shown to possess antiinflammatory properties. However, the mechanism of action behind its anti-inflammatory action is unclear. Using ...