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Bacterial and Arachnid Sphingomyelinases D: Comparison of Biophysical and Pathological Activities
(2017-08-01)
Sphingomyelinases D have only been identified in arachnid venoms, Corynebacteria, Arcanobacterium, Photobacterium and in the fungi Aspergillus and Coccidioides. The arachnid and bacterial enzymes share very low sequence ...
Membrane-damaging and cytotoxic sphingomyelinases and phospholipases
(2015-06-05)
This chapter presents an overview of the classification, structure, and main physiopathological activities of bacterial sphingomyelinases and phospholipases, providing examples of their roles as virulence factors in several ...
Membrane-damaging and cytotoxic sphingomyelinases and phospholipases
(2015-06-05)
This chapter presents an overview of the classification, structure, and main physiopathological activities of bacterial sphingomyelinases and phospholipases, providing examples of their roles as virulence factors in several ...
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
(Elsevier B.V., 2006-03-31)
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg2+ ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined ...
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
(Elsevier B.V., 2006-03-31)
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg2+ ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined ...
Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets
(Sage Publications Ltd, 2011-01)
Loxosceles venoms can promote severe local and systemic damages. We have previously reported that Loxosceles gaucho spider venom causes a severe early thrombocytopenia in rabbits. Herein, we investigated the in vitro effects ...
SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: Molecular cloning, expression, function and structural analysis
(Pergamon-Elsevier B.V. Ltd, 2009-06-01)
Sphingomyelinase D (SMase D) present in the venoms of Loxosceles spiders is the principal component responsible for local and systemic effects observed in the loxoscelism. By using "expressed sequencing tag", it was possible ...
Kinetic and mechanistic characterization of the Sphingomyelinases D from Loxosceles intermedia spider venom
(Elsevier B.V., 2006-03-15)
Envenomation by arachnids of the genus Loxosceles leads to local dermonecrosis and serious systemic toxicity mainly induced by sphingomyelinases D (SMase D). These enzymes catalyze the hydrolysis of sphingomyelin resulting ...
Kinetic and mechanistic characterization of the Sphingomyelinases D from Loxosceles intermedia spider venom
(Elsevier B.V., 2006-03-15)
Envenomation by arachnids of the genus Loxosceles leads to local dermonecrosis and serious systemic toxicity mainly induced by sphingomyelinases D (SMase D). These enzymes catalyze the hydrolysis of sphingomyelin resulting ...